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Role of the S. typhimurium Actin-Binding Protein SipA in Bacterial Internalization

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Science  26 Mar 1999:
Vol. 283, Issue 5410, pp. 2092-2095
DOI: 10.1126/science.283.5410.2092

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Abstract

Entry of the bacterium Salmonella typhimurium into host cells requires membrane ruffling and rearrangement of the actin cytoskeleton. Here, it is shown that the bacterial protein SipA plays a critical role in this process. SipA binds directly to actin, decreases its critical concentration, and inhibits depolymerization of actin filaments. These activities result in the spatial localization and more pronounced outward extension of the Salmonella-induced membrane ruffles, thereby facilitating bacterial uptake.

  • * To whom correspondence should be addressed. E-mail: jorge.galan{at}yale.edu

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