Drug Therapies for Depression: From MAO Inhibitors to Substance P

Science  09 Apr 1999:
Vol. 284, Issue 5412, pp. 239
DOI: 10.1126/science.284.5412.239

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Antidepressants have evolved through several generations since the 1950s, each a huge improvement over its predecessor--or so advocates have claimed. But a government-sponsored study published last month confirmed what other analyses had shown before: The fashionable antidepressants of the 1990s are no more effective than those of previous generations. The newer drugs do have a plus, however: fewer side effects.