Shifting RNA Polymerase into Overdrive

See allHide authors and affiliations

Science  23 Apr 1999:
Vol. 284, Issue 5414, pp. 598-599
DOI: 10.1126/science.284.5414.598

You are currently viewing the summary.

View Full Text

Log in to view the full text

Log in through your institution

Log in through your institution


DNA is transcribed into RNA by a highly conserved enzyme called RNA polymerase (RNAP). Organisms have developed elaborate methods to regulate gene expression by terminating transcription early. A report from Yarnell and Roberts, discussed by Landick in his Perspective, provides valuable insights into transcription termination and a process called overdrive in which the RNAP is able to ignore the termination sequence and transcription continues. Their findings are valuable for understanding gene regulation in both prokaryotes and eukaryotes.