PerspectiveTRANSCRIPTION

Shifting RNA Polymerase into Overdrive

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Science  23 Apr 1999:
Vol. 284, Issue 5414, pp. 598-599
DOI: 10.1126/science.284.5414.598

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Summary

DNA is transcribed into RNA by a highly conserved enzyme called RNA polymerase (RNAP). Organisms have developed elaborate methods to regulate gene expression by terminating transcription early. A report from Yarnell and Roberts, discussed by Landick in his Perspective, provides valuable insights into transcription termination and a process called overdrive in which the RNAP is able to ignore the termination sequence and transcription continues. Their findings are valuable for understanding gene regulation in both prokaryotes and eukaryotes.

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