One Ring to Rule a Superfamily of E3 Ubiquitin Ligases

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Science  23 Apr 1999:
Vol. 284, Issue 5414, pp. 601-604
DOI: 10.1126/science.284.5414.601

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The ubiquitin pathway is a sophisticated enzyme pathway that targets unwanted intracellular proteins for degradation within the proteasome. Three papers in Science suggest that there exists a superfamily of E3 ubiquitin ligases (the enzymes that tether ubiquitin to the protein marking it for degradation) present in multiprotein complexes. In their Perspective, Mike Tyers and Andrew Willems discuss these findings and what they tell us about protein degradation in the cell.