Report

Male Homosexuality: Absence of Linkage to Microsatellite Markers at Xq28

Science  23 Apr 1999:
Vol. 284, Issue 5414, pp. 665-667
DOI: 10.1126/science.284.5414.665

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Abstract

Several lines of evidence have implicated genetic factors in homosexuality. The most compelling observation has been the report of genetic linkage of male homosexuality to microsatellite markers on the X chromosome. This observation warranted further study and confirmation. Sharing of alleles at position Xq28 was studied in 52 gay male sibling pairs from Canadian families. Four markers at Xq28 were analyzed (DXS1113, BGN, Factor 8, and DXS1108). Allele and haplotype sharing for these markers was not increased over expectation. These results do not support an X-linked gene underlying male homosexuality.

  • * To whom correspondence should be addressed. E-mail grice{at}julian.uwo.ca

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