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Control of Hippocampal Morphogenesis and Neuronal Differentiation by the LIM Homeobox Gene Lhx5

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Science  14 May 1999:
Vol. 284, Issue 5417, pp. 1155-1158
DOI: 10.1126/science.284.5417.1155

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Abstract

The mammalian hippocampus contains the neural circuitry that is crucial for cognitive functions such as learning and memory. The development of such circuitry is dependent on the generation and correct placement of the appropriate number and types of neurons. Mice lacking function of the LIM homeobox gene Lhx5 showed a defect in hippocampus development. Hippocampal neural precursor cells were specified and proliferated, but many of them failed to either exit the cell cycle or to differentiate and migrate properly.Lhx5 is therefore essential for the regulation of precursor cell proliferation and the control of neuronal differentiation and migration during hippocampal development.

  • * Present address: Department of Biological Sciences, University of Tokyo, Tokyo 113, Japan.

  • To whom correspondence should be addressed. E-mail: hw{at}helix.nih.gov

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