Report

Bone Marrow as a Potential Source of Hepatic Oval Cells

Science  14 May 1999:
Vol. 284, Issue 5417, pp. 1168-1170
DOI: 10.1126/science.284.5417.1168

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Abstract

Bone marrow stem cells develop into hematopoietic and mesenchymal lineages but have not been known to participate in production of hepatocytes, biliary cells, or oval cells during liver regeneration. Cross-sex or cross-strain bone marrow and whole liver transplantation were used to trace the origin of the repopulating liver cells. Transplanted rats were treated with 2-acetylaminofluorene, to block hepatocyte proliferation, and then hepatic injury, to induce oval cell proliferation. Markers for Y chromosome, dipeptidyl peptidase IV enzyme, and L21-6 antigen were used to identify liver cells of bone marrow origin. From these cells, a proportion of the regenerated hepatic cells were shown to be donor-derived. Thus, a stem cell associated with the bone marrow has epithelial cell lineage capability.

  • Present address: Department of Oncology, King Faisal Specialist Hospital and Research Centre, Post Office Box 3354, Riyadh, Kingdom of Saudi Arabia.

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