Report

Identification of a Nuclear Receptor for Bile Acids

Science  21 May 1999:
Vol. 284, Issue 5418, pp. 1362-1365
DOI: 10.1126/science.284.5418.1362

You are currently viewing the abstract.

View Full Text

Via your Institution

Log in through your institution

Log in through your institution


Abstract

Bile acids are essential for the solubilization and transport of dietary lipids and are the major products of cholesterol catabolism. Results presented here show that bile acids are physiological ligands for the farnesoid X receptor (FXR), an orphan nuclear receptor. When bound to bile acids, FXR repressed transcription of the gene encoding cholesterol 7α-hydroxylase, which is the rate-limiting enzyme in bile acid synthesis, and activated the gene encoding intestinal bile acid–binding protein, which is a candidate bile acid transporter. These results demonstrate a mechanism by which bile acids transcriptionally regulate their biosynthesis and enterohepatic transport.

  • * These authors contributed equally to this work.

  • To whom correspondence should be addressed. E-mail: davo.mango{at}email.swmed.edu

View Full Text

Related Content