Report

Purification and Cloning of Aggrecanase-1: A Member of the ADAMTS Family of Proteins

See allHide authors and affiliations

Science  04 Jun 1999:
Vol. 284, Issue 5420, pp. 1664-1666
DOI: 10.1126/science.284.5420.1664

You are currently viewing the abstract.

View Full Text

Log in to view the full text

Log in through your institution

Log in through your institution

Abstract

We purified, cloned, and expressed aggrecanase, a protease that is thought to be responsible for the degradation of cartilage aggrecan in arthritic diseases. Aggrecanase-1 [a disintegrin and metalloproteinase with thrombospondin motifs–4 (ADAMTS-4)] is a member of the ADAMTS protein family that cleaves aggrecan at the glutamic acid-373–alanine-374 bond. The identification of this protease provides a specific target for the development of therapeutics to prevent cartilage degradation in arthritis.

  • * Present address: Department of Cancer Cell Research, Institute of Medical Science, University of Tokyo, Minato-ku, Tokyo 108–8639, Japan.

  • To whom correspondence should be addressed. E-mail: elizabeth.c.arner{at}dupontpharma.com

View Full Text