PerspectiveDevelopmental Biology

Sex and Repression

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Science  11 Jun 1999:
Vol. 284, Issue 5421, pp. 1787-1788
DOI: 10.1126/science.284.5421.1787

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In a Perspective, Kuroda and Kelley discuss the new finding ( Dawes et al.) that SDC-2, a protein with gene repressor and chromosome-wide repressor activity, can regulate both sexual development and dosage compensation (that is, equal X-linked gene expression in both XX hermaphrodite and XO male nematodes) in C. elegans. They explain how SDC-2 recruits different groups of proteins to the X chromosomes to repress different sets of genes.