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Requirement for Croquemort in Phagocytosis of Apoptotic Cells in Drosophila

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Science  18 Jun 1999:
Vol. 284, Issue 5422, pp. 1991-1994
DOI: 10.1126/science.284.5422.1991

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Abstract

Macrophages in the Drosophila embryo are responsible for the phagocytosis of apoptotic cells and are competent to engulf bacteria. Croquemort (CRQ) is a CD36-related receptor expressed exclusively on these macrophages. Genetic evidence showed thatcrq was essential for efficient phagocytosis of apoptotic corpses but was not required for the engulfment of bacteria. The expression of CRQ was regulated by the amount of apoptosis. These data define distinct pathways for the phagocytosis of corpses and bacteria in Drosophila.

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