Special Reviews

Chemical Etiology of Nucleic Acid Structure

Science  25 Jun 1999:
Vol. 284, Issue 5423, pp. 2118-2124
DOI: 10.1126/science.284.5423.2118

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Abstract

Systematic chemical studies indicate that the capability of Watson-Crick base-pairing is widespread among potentially natural nucleic acid alternatives taken from RNA's close structural neighborhood. A comparison of RNA and such alternatives with regard to chemical properties that are fundamental to the biological function of RNA provides chemical facts that may contain clues to RNA's origin.

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