Special Reviews

Chemical Etiology of Nucleic Acid Structure

See allHide authors and affiliations

Science  25 Jun 1999:
Vol. 284, Issue 5423, pp. 2118-2124
DOI: 10.1126/science.284.5423.2118

You are currently viewing the abstract.

View Full Text


Systematic chemical studies indicate that the capability of Watson-Crick base-pairing is widespread among potentially natural nucleic acid alternatives taken from RNA's close structural neighborhood. A comparison of RNA and such alternatives with regard to chemical properties that are fundamental to the biological function of RNA provides chemical facts that may contain clues to RNA's origin.

View Full Text