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A Phospholipase C-Dependent Inositol Polyphosphate Kinase Pathway Required for Efficient Messenger RNA Export

Science  02 Jul 1999:
Vol. 285, Issue 5424, pp. 96-100
DOI: 10.1126/science.285.5424.96

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Abstract

In order to identify additional factors required for nuclear export of messenger RNA, a genetic screen was conducted with a yeast mutant deficient in a factor Gle1p, which associates with the nuclear pore complex (NPC). The three genes identified encode phospholipase C and two potential inositol polyphosphate kinases. Together, these constitute a signaling pathway from phosphatidylinositol 4,5-bisphosphate to inositol hexakisphosphate (IP6). The common downstream effects of mutations in each component were deficiencies in IP6 synthesis and messenger RNA export, indicating a role for IP6 in GLE1function and messenger RNA export.

  • * To whom correspondence should be addressed. E-mail: yorkj{at}acpub.duke.edu (J.D.Y.) or swente{at}cellbio.wustl.edu(S.R.W.)

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