Dancing the Immunological Two-Step

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Science  09 Jul 1999:
Vol. 285, Issue 5425, pp. 207-208
DOI: 10.1126/science.285.5425.207

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The delicate dance between T cells and antigen presenting cells enables the T cell receptor to engage with specific peptide-MHC molecules on the surface of the antigen presenting cell, resulting in T cell activation. In his Perspective, Bernard Malissen describes the molecular choreography, revealed by real-time imaging ( Grakoui et al.), that leads to formation of immunological synapses between T cells and their partners.