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BLyS: Member of the Tumor Necrosis Factor Family and B Lymphocyte Stimulator

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Science  09 Jul 1999:
Vol. 285, Issue 5425, pp. 260-263
DOI: 10.1126/science.285.5425.260

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Abstract

The tumor necrosis factor (TNF) superfamily of cytokines includes both soluble and membrane-bound proteins that regulate immune responses. A member of the human TNF family, BLyS (B lymphocyte stimulator), was identified that induced B cell proliferation and immunoglobulin secretion. BLyS expression on human monocytes could be up-regulated by interferon-γ. Soluble BLyS functioned as a potent B cell growth factor in costimulation assays. Administration of soluble recombinant BLyS to mice disrupted splenic B and T cell zones and resulted in elevated serum immunoglobulin concentrations. The B cell tropism of BLyS is consistent with its receptor expression on B-lineage cells. The biological profile of BLyS suggests it is involved in monocyte-driven B cell activation.

  • * To whom correspondence should be addressed. E-mail: david_hilbert{at}hgsi.com

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