News of the WeekMicrobiology

Anti-Immune Trick Unveiled in Salmonella

See allHide authors and affiliations

Science  16 Jul 1999:
Vol. 285, Issue 5426, pp. 306-307
DOI: 10.1126/science.285.5426.306b

You are currently viewing the summary.

View Full Text

Log in to view the full text

Log in through your institution

Log in through your institution


In the 15 July EMBO Journal, microbiologists report on a surprising new weapon that may help explain Salmonella's virulence: At least one species can create an intracellular traffic jam within certain of the host's immune cells. The researchers found that Salmonella enterica, which causes food poisoning, shoots a protein called SpiC into the host cell's cytoplasm, somehow clogging an intracellular transport system that would normally dump the organism into a toxic cellular chamber called the lysosome.