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Anti-Immune Trick Unveiled in Salmonella

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Science  16 Jul 1999:
Vol. 285, Issue 5426, pp. 306-307
DOI: 10.1126/science.285.5426.306b

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In the 15 July EMBO Journal, microbiologists report on a surprising new weapon that may help explain Salmonella's virulence: At least one species can create an intracellular traffic jam within certain of the host's immune cells. The researchers found that Salmonella enterica, which causes food poisoning, shoots a protein called SpiC into the host cell's cytoplasm, somehow clogging an intracellular transport system that would normally dump the organism into a toxic cellular chamber called the lysosome.