Differences in Left-Right Axis Pathways in Mouse and Chick: Functions of FGF8 and SHH

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Science  16 Jul 1999:
Vol. 285, Issue 5426, pp. 403-406
DOI: 10.1126/science.285.5426.403

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A molecular pathway leading to left-right asymmetry in the chick embryo has been described, in which FGF8 is a right determinant and Sonic Hedgehog a left determinant. Here evidence is presented that theFgf8 and Sonic Hedgehog genes are required for left-right axis determination in the mouse embryo, but that they have different functions from those previously reported in the chick. In the mouse FGF8 is a left determinant and Sonic Hedgehog is required to prevent left determinants from being expressed on the right.

  • * Present address: Department of Pediatrics, Duke University Medical Center, Durham, NC 27710, USA.

  • To whom correspondence should be addressed. E-mail: gmartin{at}

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