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Prevention of Graft Versus Host Disease by Inactivation of Host Antigen-Presenting Cells

Science  16 Jul 1999:
Vol. 285, Issue 5426, pp. 412-415
DOI: 10.1126/science.285.5426.412

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Abstract

Graft versus host disease, an alloimmune attack on host tissues mounted by donor T cells, is the most important toxicity of allogeneic bone marrow transplantation. The mechanism by which allogeneic T cells are initially stimulated is unknown. In a murine allogeneic bone marrow transplantation model it was found that, despite the presence of numerous donor antigen-presenting cells, only host-derived antigen-presenting cells initiated graft versus host disease. Thus, strategies for preventing graft versus host disease could be developed that are based on inactivating host antigen-presenting cells. Such strategies could expand the safety and application of allogeneic bone marrow transplantation in treatment of common genetic and neoplastic diseases.

  • * These authors contributed equally to this work.

  • To whom correspondence should be addressed. E-mail: emersons{at}mail.med.upenn.edu

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