Report

Generation of a Widespread Drosophila Inversion by a Transposable Element

Science  16 Jul 1999:
Vol. 285, Issue 5426, pp. 415-418
DOI: 10.1126/science.285.5426.415

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Abstract

Although polymorphic inversions in Drosophila are very common, the origin of these chromosomal rearrangements is unclear. The breakpoints of the cosmopolitan inversion 2j of D. buzzatii were cloned and sequenced. Both breakpoints contain large insertions corresponding to a transposable element. It appears that the two pairs of target site duplications generated upon insertion were exchanged during the inversion event, and that the inversion arose by ectopic recombination between two copies of the transposon that were in opposite orientations. This is apparently the mechanism by which transposable elements generate natural inversions inDrosophila.

  • * To whom correspondence should be addressed (in Spain). E-mail: mariocs{at}cc.uab.es

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