Blocking Estrogen

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Science  30 Jul 1999:
Vol. 285, Issue 5428, pp. 637
DOI: 10.1126/science.285.5428.637h

The estrogen receptor is a nuclear hormone receptor that has been implicated in many breast cancers, and antiestrogens are widely prescribed to block binding of the natural ligands to the receptor. To better understand how estrogen and its agonists and antagonists interact with the estrogen receptor, Norris et al. (p. 744) used a phage display assay to identify peptides that bind differentially to various ligand-bound estrogen receptors. These binding complexes show that estrogen and the partial agonist tamoxifen interact with estrogen receptor through different mechanisms.

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