Report

An Activating Immunoreceptor Complex Formed by NKG2D and DAP10

Science  30 Jul 1999:
Vol. 285, Issue 5428, pp. 730-732
DOI: 10.1126/science.285.5428.730

You are currently viewing the abstract.

View Full Text

Via your Institution

Log in through your institution

Log in through your institution


Abstract

Many immune receptors are composed of separate ligand-binding and signal-transducing subunits. In natural killer (NK) and T cells, DAP10 was identified as a cell surface adaptor protein in an activating receptor complex with NKG2D, a receptor for the stress-inducible and tumor-associated major histocompatibility complex molecule MICA. Within the DAP10 cytoplasmic domain, an Src homology 2 (SH2) domain–binding site was capable of recruiting the p85 subunit of the phosphatidylinositol 3-kinase (PI 3-kinase), providing for NKG2D-dependent signal transduction. Thus, NKG2D-DAP10 receptor complexes may activate NK and T cell responses against MICA-bearing tumors.

  • * To whom correspondence should be addressed. E-mail: lanier{at}dnax.org

View Full Text

Cited By...