Long-Term Depression in Hippocampal Interneurons: Joint Requirement for Pre- and Postsynaptic Events

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Science  27 Aug 1999:
Vol. 285, Issue 5432, pp. 1411-1414
DOI: 10.1126/science.285.5432.1411

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Long-term depression (LTD) is a well-known form of synaptic plasticity of principal neurons in the mammalian brain. Whether such changes occur in interneurons is still controversial. CA3 hippocampal interneurons expressing Ca2+-permeable AMPA receptors exhibited LTD after tetanic stimulation of CA3 excitatory inputs. LTD was independent of NMDA receptors and required both Ca2+influx through postsynaptic AMPA receptors and activation of presynaptic mGluR7-like receptors. These results point to the capability of interneurons to undergo plastic changes of synaptic strength through joint activation of pre- and postsynaptic glutamate receptors.

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