Review

Long-Term Potentiation--A Decade of Progress?

Science  17 Sep 1999:
Vol. 285, Issue 5435, pp. 1870-1874
DOI: 10.1126/science.285.5435.1870

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Abstract

Long-term potentiation of synaptic transmission in the hippocampus is the leading experimental model for the synaptic changes that may underlie learning and memory. This review presents a current understanding of the molecular mechanisms of this long-lasting increase in synaptic strength and describes a simple model that unifies much of the data that previously were viewed as contradictory.

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