PerspectiveCell Biology

All Creatures Great and Small

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Science  24 Sep 1999:
Vol. 285, Issue 5436, pp. 2082-2083
DOI: 10.1126/science.285.5436.2082

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It is a mystery how multicellular organisms regulate the size of their cells and their overall mass. A number of papers, using the fruit fly Drosophila as a model system, now show that different molecules along the pathway that transduces signals from the insulin receptor and its ligand are involved in regulating cell size and growth rate. Sally Leevers ties together the findings of these different studies in an illuminating Perspective.