Report

A Nonpeptidyl Mimic of Superoxide Dismutase with Therapeutic Activity in Rats

Science  08 Oct 1999:
Vol. 286, Issue 5438, pp. 304-306
DOI: 10.1126/science.286.5438.304

You are currently viewing the abstract.

View Full Text
As a service to the community, AAAS/Science has made this article free with registration.

Abstract

Many human diseases are associated with the overproduction of oxygen free radicals that inflict cell damage. A manganese(II) complex with a bis(cyclohexylpyridine)-substituted macrocyclic ligand (M40403) was designed to be a functional mimic of the superoxide dismutase (SOD) enzymes that normally remove these radicals. M40403 had high catalytic SOD activity and was chemically and biologically stable in vivo. Injection of M40403 into rat models of inflammation and ischemia-reperfusion injury protected the animals against tissue damage. Such mimics may result in better clinical therapies for diseases mediated by superoxide radicals.

  • * To whom correspondence should be addressed. E-mail: dsalvemini{at}metaphore.com

View Full Text

Cited By...