Coordinated Polar Localization of Auxin Efflux Carrier PIN1 by GNOM ARF GEF

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Science  08 Oct 1999:
Vol. 286, Issue 5438, pp. 316-318
DOI: 10.1126/science.286.5438.316

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The plant hormone auxin is transported in a polar manner along the shoot-root axis, which requires efflux carriers such as PIN1. Asymmetric localization of PIN1 develops from a random distribution inArabidopsis early embryogenesis. Coordinated polar localization of PIN1 is defective in gnom embryos. GNOM is a membrane-associated guanine-nucleotide exchange factor on ADP-ribosylation factor G protein (ARF GEF). Thus, GNOM-dependent vesicle trafficking may establish cell polarity, resulting in polar auxin transport.

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