Review

The Promise of Comparative Genomics in Mammals

Science  15 Oct 1999:
Vol. 286, Issue 5439, pp. 458-481
DOI: 10.1126/science.286.5439.458

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Abstract

Dense genetic maps of human, mouse, and rat genomes that are based on coding genes and on microsatellite and single-nucleotide polymorphism markers have been complemented by precise gene homolog alignment with moderate-resolution maps of livestock, companion animals, and additional mammal species. Comparative genetic assessment expands the utility of these maps in gene discovery, in functional genomics, and in tracking the evolutionary forces that sculpted the genome organization of modern mammalian species.

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