News FocusMolecular Biology

A New Blocker for the TGF-β Pathway

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Science  22 Oct 1999:
Vol. 286, Issue 5440, pp. 665
DOI: 10.1126/science.286.5440.665

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For more than a decade, researchers have suspected that two proteins known as Ski and Sno play a role in the unrestrained cell growth that leads to cancer, but because no one was able to determine their role in the cell, they received little attention. Now five separate papers--including one on page 771 of this issue--show that Ski and Sno can block one of the cell's major growth-controlling pathways, the transforming growth factor-b signal. The finding puts the proteins at the center of one of the hottest areas of cell biology and sheds new light on this ubiquitous pathway.