Arabidopsis NPH3: A NPH1 Photoreceptor-Interacting Protein Essential for Phototropism

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Science  29 Oct 1999:
Vol. 286, Issue 5441, pp. 961-964
DOI: 10.1126/science.286.5441.961

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Phototropism of Arabidopsis thalianaseedlings in response to a blue light source is initiated by nonphototropic hypocotyl 1 (NPH1), a light-activated serine-threonine protein kinase. Mutations in three loci [NPH2, root phototropism 2 (RPT2), and NPH3] disrupt early signaling occurring downstream of the NPH1 photoreceptor. TheNPH3 gene, now cloned, encodes a NPH1-interacting protein. NPH3 is a member of a large protein family, apparently specific to higher plants, and may function as an adapter or scaffold protein to bring together the enzymatic components of a NPH1-activated phosphorelay.

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