Breast Cancer Genes and DNA Repair

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Science  05 Nov 1999:
Vol. 286, Issue 5442, pp. 1100-1102
DOI: 10.1126/science.286.5442.1100

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It is still not clear what the proteins encoded by the breast cancer susceptibility genes, BRCA1 and BRCA2, do in the cell. In a Perspective, Ashok Venkitaraman discusses recent findings ( Cortez et al.) showing that phosphorylation of BRCA1 by a protein kinase called ATM is necessary for the cell to repair DNA damage induced by gradiation.