PerspectiveCell Biology

Cell Migration--Movin' On

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Science  05 Nov 1999:
Vol. 286, Issue 5442, pp. 1102-1103
DOI: 10.1126/science.286.5442.1102

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Cell movement is an elegant orchestration of different cellular processes that include microtubule dynamics, contraction of actin and myosin filaments, and the formation and turnover of integrin-rich adhesion complexes that serve as traction points over which the cell moves. In a comprehensive overview Perspective, Horwitz and Parsons discuss the mechanisms that regulate the dynamics of contractile forces and adhesion. New findings suggest the existence of a molecular `clutch' that regulates the balance of these processes ( Smilenov et al.).