PerspectiveSignal Transduction

Cell Survival Demands Some Rsk

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Science  12 Nov 1999:
Vol. 286, Issue 5443, pp. 1309-1310
DOI: 10.1126/science.286.5443.1309

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MAPKs are involved in many cellular processes such as cell survival, chromatin remodeling, and cell division. Nebreda and Gavin discuss new findings showing that the downstream effectors of MAPK activity are the Rsk protein kinases that can phosphorylate transcription factors, histones, and kinases involved in the cell cycle (Bhatt and Ferrell, Bonni et al., Gross et al .).

A. R. Nebreda is at the European Molecular Biology Laboratory, Meyerhofstrasse 1, 69117 Heidelberg, Germany. E-mail: A.-C. Gavin is in the Institut für Physiologie der Universität Basel, Vesalgasse1, CH-4051 Basel, Switzerland. E-mail: