Sexual Transmission and Propagation of SIV and HIV in Resting and Activated CD4+ T Cells

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Science  12 Nov 1999:
Vol. 286, Issue 5443, pp. 1353-1357
DOI: 10.1126/science.286.5443.1353

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In sexual transmission of simian immunodeficiency virus, and early and later stages of human immunodeficiency virus–type 1 (HIV-1) infection, both viruses were found to replicate predominantly in CD4+ T cells at the portal of entry and in lymphoid tissues. Infection was propagated not only in activated and proliferating T cells but also, surprisingly, in resting T cells. The infected proliferating cells correspond to the short-lived population that produces the bulk of HIV-1. Most of the HIV-1–infected resting T cells persisted after antiretroviral therapy. Latently and chronically infected cells that may be derived from this population pose challenges to eradicating infection and developing an effective vaccine.

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