"Sickle Cell Anemia, a Molecular Disease"

Science  19 Nov 1999:
Vol. 286, Issue 5444, pp. 1488-1490
DOI: 10.1126/science.286.5444.1488

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Fifty years ago this month, Linus Pauling published his seminal Science paper describing the difference in electrophoretic mobilities between normal hemoglobin and that from patients with sickle cell anemia. In so doing he founded the field of molecular medicine, as Strasser explains in a lively Perspective that looks at the discovery and its aftermath.