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Specific Lipopolysaccharide Found in Cystic Fibrosis Airway Pseudomonas aeruginosa

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Science  19 Nov 1999:
Vol. 286, Issue 5444, pp. 1561-1565
DOI: 10.1126/science.286.5444.1561

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Abstract

Cystic fibrosis (CF) patients develop chronic airway infections with Pseudomonas aeruginosa (PA).Pseudomonas aeruginosa synthesized lipopolysaccharide (LPS) with a variety of penta- and hexa-acylated lipid A structures under different environmental conditions. CF patient PA synthesized LPS with specific lipid A structures indicating unique recognition of the CF airway environment. CF-specific lipid A forms containing palmitate and aminoarabinose were associated with resistance to cationic antimicrobial peptides and increased inflammatory responses, indicating that they are likely to be involved in airway disease.

  • * Present address: Immunex Corporation, 51 University Street, Seattle, WA 98101, USA.

  • Present address: Bristol-Myers Squibb, Pharmaceutical Research Institute, Post Office Box 4000, Princeton, NJ 08543, USA.

  • To whom correspondence should be addressed. E-mail: millersi{at}u.washington.edu

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