Report

Specific Lipopolysaccharide Found in Cystic Fibrosis Airway Pseudomonas aeruginosa

+ See all authors and affiliations

Science  19 Nov 1999:
Vol. 286, Issue 5444, pp. 1561-1565
DOI: 10.1126/science.286.5444.1561

You are currently viewing the abstract.

View Full Text

Via your Institution

Log in through your institution

Log in through your institution


Abstract

Cystic fibrosis (CF) patients develop chronic airway infections with Pseudomonas aeruginosa (PA).Pseudomonas aeruginosa synthesized lipopolysaccharide (LPS) with a variety of penta- and hexa-acylated lipid A structures under different environmental conditions. CF patient PA synthesized LPS with specific lipid A structures indicating unique recognition of the CF airway environment. CF-specific lipid A forms containing palmitate and aminoarabinose were associated with resistance to cationic antimicrobial peptides and increased inflammatory responses, indicating that they are likely to be involved in airway disease.

  • * Present address: Immunex Corporation, 51 University Street, Seattle, WA 98101, USA.

  • Present address: Bristol-Myers Squibb, Pharmaceutical Research Institute, Post Office Box 4000, Princeton, NJ 08543, USA.

  • To whom correspondence should be addressed. E-mail: millersi{at}u.washington.edu

View Full Text

Related Content