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Arthritis Provoked by Linked T and B Cell Recognition of a Glycolytic Enzyme

Science  26 Nov 1999:
Vol. 286, Issue 5445, pp. 1732-1735
DOI: 10.1126/science.286.5445.1732

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Abstract

The hallmark of rheumatoid arthritis (RA) is specific destruction of the synovial joints. In a mouse line that spontaneously develops a disorder with many of the features of human RA, disease is initiated by T cell recognition of a ubiquitously expressed self-antigen; once initiated, pathology is driven almost entirely by immunoglobulins. In this study, the target of both the initiating T cells and pathogenic immunoglobulins was identified as glucose-6-phosphate isomerase, a glycolytic enzyme. Thus, some forms of RA or related arthritides may develop by a mechanism fundamentally different from the currently popular paradigm of a joint-specific T cell response.

  • * Present address: Joslin Diabetes Center, Harvard Medical School, One Joslin Place, Boston, MA 02215, USA.

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