Differentiation Stage-Specific Inhibition of the Raf-MEK-ERK Pathway by Akt

Science  26 Nov 1999:
Vol. 286, Issue 5445, pp. 1738-1741
DOI: 10.1126/science.286.5445.1738

You are currently viewing the abstract.

View Full Text

Via your Institution

Log in through your institution

Log in through your institution

This article has a correction. Please see:


Extracellular signals often result in simultaneous activation of both the Raf-MEK-ERK and PI3K-Akt pathways (where ERK is extracellular-regulated kinase, MEK is mitogen-activated protein kinase or ERK kinase, and PI3K is phosphatidylinositol 3-kinase). However, these two signaling pathways were shown to exert opposing effects on muscle cell hypertrophy. Furthermore, the PI3K-Akt pathway was shown to inhibit the Raf-MEK-ERK pathway; this cross-regulation depended on the differentiation state of the cell: Akt activation inhibited the Raf-MEK-ERK pathway in differentiated myotubes, but not in their myoblast precursors. The stage-specific inhibitory action of Akt correlated with its stage-specific ability to form a complex with Raf, suggesting the existence of differentially expressed mediators of an inhibitory Akt-Raf complex.

  • * To whom correspondence should be addressed. E-mail:{at}

View Full Text

Cited By...