PerspectivePROTEIN STRUCTURE

Class-Conscious TCR?

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Science  03 Dec 1999:
Vol. 286, Issue 5446, pp. 1867-1868
DOI: 10.1126/science.286.5446.1867

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Summary

Resolution of the structure of the T cell receptor (TCR) bound to a complex between an MHC class I molecule and a peptide of processed antigen sheds new light on the molecular complexities of this interaction. Now, in a Perspective, Ian Wilson discusses new work ( Reinherz et al.) that reveals the structure of TCR bound to an MHC class II-peptide complex and compares and contrasts the two classes of structure.