Report

Requirement for B Cell Linker Protein (BLNK) in B Cell Development

Science  03 Dec 1999:
Vol. 286, Issue 5446, pp. 1949-1954
DOI: 10.1126/science.286.5446.1949

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Abstract

Linker proteins function as molecular scaffolds to localize enzymes with substrates. In B cells, B cell linker protein (BLNK) links the B cell receptor (BCR)–activated Syk kinase to the phosphoinositide and mitogen-activated kinase pathways. To examine the in vivo role of BLNK, mice deficient in BLNK were generated. B cell development in BLNK −/− mice was blocked at the transition from B220+CD43+ progenitor B to B220+CD43 precursor B cells. Only a small percentage of immunoglobulin M++ (IgM++), but not mature IgMloIgDhi, B cells were detected in the periphery. Hence, BLNK is an essential component of BCR signaling pathways and is required to promote B cell development.

  • * To whom correspondence should be addressed. E-mail: achan{at}im.wustl.edu

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