Report

Posttranscriptional Gene Silencing in Neurospora by a RecQ DNA Helicase

See allHide authors and affiliations

Science  17 Dec 1999:
Vol. 286, Issue 5448, pp. 2342-2344
DOI: 10.1126/science.286.5448.2342

You are currently viewing the abstract.

View Full Text

Log in to view the full text

Log in through your institution

Log in through your institution

Abstract

The phenomenon of posttranscriptional gene silencing (PTGS), which occurs when a transgene is introduced into a cell, is poorly understood. Here, the qde-3 gene, which is required for the activation and maintenance of gene silencing in the fungusNeurospora crassa, was isolated. Sequence analysis revealed that the qde-3 gene belongs to the RecQ DNA helicase family. The QDE3 protein may function in the DNA-DNA interaction between introduced transgenes or with an endogenous gene required for gene-silencing activation. In animals, genes that are homologous to RecQ protein, such as the human genes for Bloom's syndrome and Werner's syndrome, may also function in PTGS.

  • * To whom correspondence should be addressed. E-mail: carlo{at}bce.med.uniroma1.it

View Full Text