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Evolution of Shape Complementarity and Catalytic Efficiency from a Primordial Antibody Template

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Science  17 Dec 1999:
Vol. 286, Issue 5448, pp. 2345-2348
DOI: 10.1126/science.286.5448.2345

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Abstract

The crystal structure of an efficient Diels-Alder antibody catalyst at 1.9 angstrom resolution reveals almost perfect shape complementarity with its transition state analog. Comparison with highly related progesterone and Diels-Alderase antibodies that arose from the same primordial germ line template shows the relatively subtle mutational steps that were able to evolve both structural complementarity and catalytic efficiency.

  • * Present address: Molecular Simulations Inc., 9685 Scranton Road, San Diego, CA 92121, USA.

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