News FocusBiochemistry

DNA Cuts Its Teeth--As an Enzyme

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Science  24 Dec 1999:
Vol. 286, Issue 5449, pp. 2441-2442
DOI: 10.1126/science.286.5449.2441

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Researchers now have a new class of molecules for inactivating genes: DNA enzymes, which can bind to and cleave the genes' RNA messages. No DNA enzymes are known in nature, however, and so they have mainly been laboratory curiosities. But in work reported in the November issue of Nature Medicine, researchers showed that a DNA enzyme can slow the narrowing of coronary arteries that have been opened with balloon angioplasty in a rat model of heart disease.