The CRYs of Flies and Mice

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Science  24 Dec 1999:
Vol. 286, Issue 5449, pp. 2460-2461
DOI: 10.1126/science.286.5449.2460

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It was recently discovered that the CRY protein in Drosophila is a photoreceptor that detects extrinsic light stimuli and is a crucial player in maintaining the circadian rhythm of the fruit fly. Subsequently, it was presumed that the CRY proteins in mice also subserve the same function. Now, Paul Hardin and Nicholas Glossop in a Perspective, relates the surprising finding that the CRYS of mice are not circadian photoreceptors but instead serve as inhibitors in the endogenous oscillator itself ( Okamura et al. ).