Reading the Worm Genome

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Science  07 Jan 2000:
Vol. 287, Issue 5450, pp. 52-53
DOI: 10.1126/science.287.5450.52

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The genome sequencing of complex organisms has reaped a wealth of information about genes. The next step is to find out what the proteins encoded by these genes do and how they interact with each other. In a Perspective, Stuart Kim, discusses the application of yeast two-hybrid technology to working out the complex interactions between the many proteins of the worm C. elegans ( Walhout et al. ). This new work is a first step in the creation of a global protein interaction map for the nematode.