Review

Memory--a Century of Consolidation

Science  14 Jan 2000:
Vol. 287, Issue 5451, pp. 248-251
DOI: 10.1126/science.287.5451.248

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Abstract

The memory consolidation hypothesis proposed 100 years ago by Müller and Pilzecker continues to guide memory research. The hypothesis that new memories consolidate slowly over time has stimulated studies revealing the hormonal and neural influences regulating memory consolidation, as well as molecular and cellular mechanisms. This review examines the progress made over the century in understanding the time-dependent processes that create our lasting memories.

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