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A Population of Murine γδ T Cells That Recognize an Inducible MHC Class Ib Molecule

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Science  14 Jan 2000:
Vol. 287, Issue 5451, pp. 314-316
DOI: 10.1126/science.287.5451.314

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Abstract

Although γδ T cells are implicated in regulating immune responses, γδ T cell–ligand pairs that could mediate such regulatory functions have not been identified. Here, the expression of the major histocompatibility complex (MHC) class Ib T22 and the closely related T10 molecules is shown to be activation-induced, and they confer specificity to about 0.4% of the γδ T cells in normal mice. Thus, the increased expression of T22 and/or T10 might trigger immunoregulatory γδ T cells during immune responses. Furthermore, the fast on-rates and slow off-rates that characterize this receptor/ligand interaction would compensate for the low ligand stability and suggest a high threshold for γδ T cell activation.

  • * Present address: Howard Hughes Medical Institute, Duke University Medical Center, Durham, NC 27705, USA.

  • Present address: Division of Immunology and Cell Biology, John Curtin School of Medical Research, Canberra, ACT, Australia.

  • Present address: Stanford Research Institute, Menlo Park, CA 94025, USA.

  • § Present address: Department of Pathology, University of California San Francisco School of Medicine, San Francisco, CA 94143, USA.

  • || To whom correspondence should be addressed. E-mail: chien{at}leland.stanford.edu

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