Report

Requirement of CD9 on the Egg Plasma Membrane for Fertilization

Science  14 Jan 2000:
Vol. 287, Issue 5451, pp. 321-324
DOI: 10.1126/science.287.5451.321

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Abstract

CD9 is an integral membrane protein associated with integrins and other membrane proteins. Mice lacking CD9 were produced by homologous recombination. Both male and female CD9−/− mice were born healthy and grew normally. However, the litter size from CD9−/− females was less than 2% of that of the wild type. In vitro fertilization experiments indicated that the cause of this infertility was due to the failure of sperm-egg fusion. When sperm were injected into oocytes with assisted microfertilization techniques, however, the fertilized eggs developed to term. These results indicate that CD9 has a crucial role in sperm-egg fusion.

  • * These authors contributed equally to this work.

  • To whom correspondence should be addressed. E-mail: emekada{at}lsi.kurume-u.ac.jp

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