HOT PICKS

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Science  28 Jan 2000:
Vol. 287, Issue 5453, pp. 543
DOI: 10.1126/science.287.5453.543c

The darndest places. Searchlight, a University of California (UC) search engine that combs scores of databases, can save time and find info you might not have even known you needed. Enter key words and it prowls the usual joints—MEDLINE, the UC catalogs, specialty databases for AIDS or cancer research. But it also digs up hits from more obscure sources. If your topic is covered in Department of Energy technical reports, National Science Foundation grant write-ups, the Patent Office, Fish and Wildlife databases, or congressional reports, Searchlight will take you there. searchlight.cdlib.org/cgi-bin/searchlight

The turn of the screw. Archimedes groupies can learn more about the Greek mathematician's breakthroughs at this site. In addition to biographical and bibliographical information, it offers descriptions of his most famous discoveries—including the eponymous water-pumping device and his work with levers—as well as tidbits on less memorable inventions, such as a mirror that focused sunlight to burn enemy ships. www.mcs.drexel.edu/∼crorres/Archimedes/contents.html

Pharmacokinetics unbound. Need to know how tightly your drug candidate binds to a particular G-protein receptor, a class of proteins through which many pharmaceutical agents exert their therapeutic effects? This new database from a psychoactive drug screening program offers thousands of affinity constants (k) for ligand binding to over 125 receptors. PDSP.cwru.edu/PDSP.asp

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