HIV Infection and Dementia

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Science  28 Jan 2000:
Vol. 287, Issue 5453, pp. 602-604
DOI: 10.1126/science.287.5453.602

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One of the characteristics of end-stage HIV infection is dementia, the exact causes of which remain elusive. In a Perspective, Gartner debates the evidence for the hypothesis that the trigger for the initiation of HIV-associated dementia is the activation of monocytes in the bone marrow and their transmigration into the brain.