Regeneration in the Nogo Zone

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Science  04 Feb 2000:
Vol. 287, Issue 5454, pp. 813-814
DOI: 10.1126/science.287.5454.813

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It has long been known that whereas peripheral nerves show some ability to regenerate, nerves in the brain and spinal cord are unable to regenerate at all after injury. In a Perspective, Tessier-Lavigne and Goodman discuss three recent papers that report the identity and characterization of a factor called Nogo-A that can inhibit nerve regeneration in culture. These findings will promote studies to discover whether blocking Nogo-A will be of benefit in treating spinal cord injuries.